neurological diseases or disorders affect a person’s functional abilities. Discuss the cause and incidence of one of the diseases/disorders listed below. Describe the pathology that occurs to the nervous system (that is what happens to neurons), and the neuroanatomical pathways involved that produces the symptoms of the disease

Task instructions:
Your assessment must submitted as a Word (or Word readable) document using a 12 point font. It is to be 1200 (± 10%) words.
References:
• At least five references (primary authoritative sources such as peer-reviewed journal articles) should be included.
• References should be cited correctly, and presented correctly in text using the author, date style of referencing (Harvard style)
• Using PubMed or Google Scholar you should include two recent research studies on the topic – these can involve humans or preclinical models (mice/rats). For each of these discuss briefly the research findings and state why this study is important in the overall field.
Submission date/time: Friday 2nd OCTOBER
Mode of submission: Via Canvas NOTE: your submission must not just contain course lecture material and will be checked by Turnitin.
Assessment criteria: Your assessment will be assessed based on content, scientific accuracy, and professional expression and use of quality sources (see over).
Topics
The topics options for the assignment are listed below. Once you have decided which topic you wish to pursue please join the group in People on Canvas for that topic. Total number of people per topic will be capped at 40 – if you change your mind you can allocate to a different group if there are still places. While you can discuss the topic with other people in your group, this is an individual assignment and will be assessed accordingly.
Disease based topics
How neurological diseases or disorders affect a person’s functional abilities. Discuss the cause and incidence of one of the diseases/disorders listed below. Describe the pathology that occurs to the nervous system (that is what happens to neurons), and the neuroanatomical pathways involved that produces the symptoms of the disease. Remember to include two recent research studies on the topic (see references section above).
1. Multiple sclerosis
2. Schizophrenia
3. Post-traumatic stress disorder
4. Autism spectrum disorder
5. Stroke (focus on a type of stroke)
6. Anopsia (focus on a type of anopsia) 
Other topics
7. Obesity and its central mechanisms
o Hypothalamic mediators of obesity, the role of stress in facilitating this disruption in the feeding circuitry, and early life determinants of obesity
8. Tracing neuronal pathways
o Describe the mechanism and methodology of two different tracing techniques used in animal models (for example HRP, rabies, autoradiography) and describe 2 recent studies using the technique.
9. Central Sensitisation and its role in chronic pain
o Discuss the mechanisms underlying central sensitization and the parts of the nervous system that undergo alteration.
o Compare and contrast hyperalgesia and allodynia.
o Briefly summarise two recent research studies focused on central sensitization (these primary research papers can be located using PubMed or Google Scholar). For each study, state why this study is important in the overall field of pain research and what it means for pain management.
10. Motor related
o Discuss the role of the Reticular Activating System (RAS) in regulating muscle activity and muscle tone during sleep. What sleep-related disorders might be attributable to dysfunction of the RAS?
o Discuss the neurochemistry thought to explain Parkinson’s and Huntington’s Diseases, and the probable site(s) of these neuropathologies in the brain.
o Discuss the contribution of Wilder Penfield to the mapping of cortical function, and if recent developments in medical imaging support the idea of a cortical sensori/motor ‘homunculus’.
11. Discuss the link between congenital CMV infection and cerebral palsy.
o Include a description of what cerebral palsy is, the known causes and the damage that can occur to the brain. Also describe what cytomegalovirus is, and the mechanisms of injury and pathogenesis to the foetal brain.
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